Noncoding RNAs in pediatric brain tumors: Molecular functions and pathological implications

Brain tumors are common solid pediatric malignancies and the main reason for cancer-related death in setting. Recently, evidence has revealed that noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long ncRNAs (lncRNAs), circular (circRNAs), play a critical role brain tumor development progression. Therefore, this review article, we describe functions molecular mechanisms of multiple types cancer, medulloblastoma, pilocytic astrocytoma, ependymoma, atypical teratoid/rhabdoid tumor, glioblastoma, diffuse intrinsic pontine glioma, craniopharyngioma. We also mention limitations using as therapeutic targets because nonspecificity ncRNA delivery methods ncRNAs. Due to oncogenesis, targeting aberrantly expressed might be an effective strategy improve outcomes patients with tumors.